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Cord blood stem cells

Using Stem Cells to Treat Diseases

Cord blood stem cells has been expensively used for therapies as compared to any other sources due to its ready availability and nascent nature delivering better results post therapy. Apart from this the lesser matching required for a therapy using cord blood stem cells as compared to other sources of haemopoetic stem cells makes it the choice of every therapist minimizing the risk associated post therapy. Around 25 years ago, the first human transplant using umbilical cord blood stem cells was performed. At the time, only one disease was treatable using cord blood stem cells. Today, cord blood stem cells can be used in the treatment of nearly 80 diseases and the list continues to develop. Cord blood stem cells have proven track records on treatment of diseases like Thalassemia, Leukemia, Anaemia, Cerebral palsy, Diabetes and various, Blood disorders, Bone marrow syndromes, Cancers, Hemoglobinopathies, Immunodeficiencies, Metabolic disorders. Further more than 300 diseases and conditions are in research progressing towards positive results. New medical technology may well use these cells to rebuild cardiac tissue, repair damage due to stroke or spinal cord injuries and reverse the effects of such diseases as multiple sclerosis or Parkinson’s. While the research is still in its early stages, the possibilities are extremely promising. And, banking your child’s stem cells increases access to any of these technologies in the future

List of Treatable Diseases

Cord blood stem cell transplants have already changed—and saved—thousands of lives around the world. They have already been used to treat more than 75 diseases, including numerous types of malignancies, anemia’s, inherited metabolic disorders and deficiencies of the immune system.

Acute Leukemia

  • Acute Lymphoblastic Leukemia (ALL)
  • Acute Myelogenous Leukemia (AML)
  • Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia

Chronic Leukemia

  • Acute Myelofibrosis
  • Agnogenic Myeloid Metaplasia (myelofibrosis)
  • Polycythemia Vera
  • Essential Thrombocythemia

Myelodysplastic Syndromes

  • Chronic Myelogenous Leukemia (CML)
  • Chronic Lymphocytic Leukemia (CLL)
  • Juvenile Chronic Myelogenous Leukemia (JCML)
  • Juvenile Myelomonocytic Leukemia (JMML)

Lymphoproliferative Disorders

  • Non-Hodgkin’s Lymphoma
  • Hodgkin’s Disease

Phagocyte Disorders

  • Chediak-Higashi Syndrome
  • Chronic Granulomatous Disease
  • Neutrophil Actin Deficiency
  • Reticular Dysgenesis

Inherited Metabolic Disorders

  • Mucopolysaccharidoses (MPS)
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  • Hurler’s Syndrome (MPS-IH)
  • Scheie Syndrome (MPS-IS)
  • Hunter’s Syndrome (MPS-II)
  • Sanfilippo Syndrome (MPS-III)
  • Morquio Syndrome (MPS-IV)
  • Maroteaux-Lamy Syndrome (MPS-VI)
  • Sly Syndrome, Beta-Glucuronidase Deficiency (MPS-VII)
  • Adrenoleukodystrophy
  • Mucolipidosis II (I-cell Disease)
  • Krabbe Disease
  • Gaucher’s Disease
  • Niemann-Pick Disease
  • Wolman Disease
  • Metachromatic Leukodystrophy

Histiocytic Disorders

  • Familial Erythrophagocytic Lymphohistiocytosis
  • Histiocytosis-X
  • Hemophagocytosis

Inherited Erythrocyte Abnormalities

  • Beta Thalassemia Major
  • Sickle Cell Disease

Inherited Immune System Disorders

  • Ataxia-Telangiectasia
  • Kostmann Syndrome
  • Leukocyte Adhesion Deficiency
  • DiGeorge Syndrome
  • Bare Lymphocyte Syndrome
  • Omenn’s Syndrome
  • Severe Combined Immunodeficiency (SCID)
  • SCID with Adenosine Deaminase Deficiency

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  • Absence of T & B Cells SCID
  • Absence of T Cells, Normal B Cell SCID
  • Common Variable Immunodeficiency
  • Wiskott-Aldrich Syndrome
  • X-Linked Lymphoproliferative Disorder

Other Inherited Disorders

  • Lesch-Nyhan Syndrome
  • Cartilage-Hair Hypoplasia
  • Glanzmann Thrombasthenia
  • Osteopetrosis

Inherited Platelet Abnormalities

  • Amegakaryocytosis / Congenital Thrombocytopenia

Plasma Cell Disorders

  • Multiple Myeloma
  • Plasma Cell Leukemia
  • Waldenstrom’s Macroglobulinemia

Other Malignancies

  • Breast Cancer
  • Wing Sarcoma
  • Neuroblastoma
  • Renal Cell Carcinoma

Future Potential

Scientists are predicting that in the near future the collection of cord blood at birth will be nearly as common as birth itself. More than the existing uses of , research indicates that these stem cells someday may be used to treat numerous other diseases including

Clinical Trial

StatusSponsorClinical Trials Gov.
Identifier
Hematologic Neoplasms
Bone Marrow Failure Syndromes
Recruiting participantsUniversity of British Columbia, CanadaNCT00897260
Traumatic Brain InjuryRecruiting participants (Phase II)The University of Texas Health Science
Center, Houston, USA
NCT01251003
Hematologic MalignanciesRecruiting participants (Phase II)Fred Hutchinson Cancer Research
Center, USA
NCT01175785
Inborn Errors of MetabolismRecruiting participants (Phase I)Duke University, USANCT00692926
Cerebral PalsyRecruiting participants (Phase II)Duke University, USANCT01147653
Leukemia Lymphoma Multiple
Myeloma Aplastic Anemia
Recruiting participants (Phase II)Tufts Medical Center, USANCT00676806
Spinal cord injuriesRecruiting participants (Phase II)China Spinal Cord Injury Network, ChinaNCT01046786
Hematologic MalignanciesRecruiting participants (Phase II)Memorial Sloan-Kettering Cancer Center, USANCT00739141
Hearing LossRecruiting participants (Phase I)Memorial Hermann Healthcare
System, USA
NCT01343394
Hypoplastic Left Heart
Syndrome
Recruiting participants (Phase I)Duke University, USANCT01445041
Type 1 DiabetesRecruiting participants (Phase I)University of Florida, USANCT00873925
Myelodysplastic Syndrome (MDS)
Severe Aplastic Anemia (SAA)
Recruiting participants (Phase I)National Heart, Lung, and Blood Institute (NHLBI), USANCT00604201

Banking & Benefits

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